By Amitava Dasgupta
This functional, easy-to-use advisor, named to Doody’s middle Titles 2013, addresses interference concerns in all laboratory assessments, together with sufferer epigenetics, means of specimen assortment, enzymes, biomarkers. Clinicians and laboratory scientists can for that reason depend on one reference which speaks to either their wishes of exact specimen research and optimum sufferer care.
Erroneous clinic and pathology laboratory effects may be complicated and difficult, particularly in acute care occasions. whereas a few components growing interference, will be pointed out within the laboratory, detecting many others is frequently depending on scientific info unavailable to the laboratory scientists or pathologists. consequently, clinicians needs to develop into expert in deciding upon such misguided experiences, and dealing with pathologists and laboratory scientists on the way to comprehend the resource of such interferences, right the implications, after which make a decision what plan of action has to be for correct sufferer management.
- Named to Doody’s middle Titles 2013, a set improvement instrument for future health sciences libraries of all sizes, through Doody Enterprises
- Practical info for either clinicians and laboratory scientists, awarded within the type of tables and charts for simple reference
- Focus on variety and resources of interferences instead of info of toxicologic mechanisms that are good coated in toxicology textbooks
- Covers interferences throughout endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing
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Additional info for Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction
Int J Lab Hematol 2010;32:491À7. Gerhardt W, Nordin G, Herbert AK, Burzell BL, et al. Troponin T and I assays show decreased concentrations in heparin plasma compared with serum: lower recoveries in early than in late phases of myocardial injury. Clin Chem 2000;46:817À21. Daves M, Trevisan D, Cemin R. Different collection tubes in cardiac biomarkers detection. J Clin Lab Anal 2008;22:391À4. McCall RE, Tankersley CM. Phlebotomy essentials. 3rd ed. Baltimore: Lippincott Williams & Wilkins; 2005. Henry JB.
Inappropriately high heparin: blood ratios can cause prolonged clotting times and increased fibrin microclots. Gerhardt et al.  suggest that binding of heparin to troponins decreases immunoreactivity and hence lowers cardiac troponin levels by 15% compared to serum. In contrast, Daves et al. , using tubes from a different manufacturer, demonstrated no interference from heparin but, rather, from the separator gel in Terumo Venosafe tubes. COLLECTION SITES; DIFFERENCES BETWEEN ARTERIAL, CAPILLARY, AND VENOUS BLOOD SAMPLES; AND PROBLEMS WITH COLLECTIONS FROM CATHETERS AND INTRAVENOUS LINES Although a wide range of specimens are occasionally analyzed in the clinically laboratory, the primary specimen is blood in one form or another.
Processing controls in blood collection tubes reveals interference. Clin Chem 2005;51:2422À3.  Bowen RA, Hortin GL, Csako G, Otan˜ez OH, et al. Impact of blood collection devices on clinical chemistry assays. Clin Biochem 2010;43:24À5.  Ernst DJ. Applied phlebotomy. Baltimore: Lippincott Williams & Wilkins; 2005.  Selby C. Interference in immunoassay. Ann Clin Biochem 1999;36:704À21.  Bowen RA, Chan Y, Cohen J, Rehak NN, et al. Effect of blood collection tubes on total triiodothyronine and other laboratory assays.